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153Samarium-EDTMP administração seguido pelo suporte de células tronco hematopoiéticas para metástases ósseas em pacientes com osteossarcoma

Postado em: 13/07/2012

153Samarium-EDTMP administration followed by hematopoietic stem cell support for bone metastases in osteosarcoma patients

Autor(es): Berger M; Grignani G; Giostra A; Ferrari S; Ferraresi V; Tamburini A; Cefalo G; Carnevale-Schianca F; Vassallo E; Picci P; Pagano M; Aglietta M; Pellerito RE; Fagioli F
Fonte: Ann Oncol; 23(7): 1899-905, 2012 Jul.
Artigo [MEDLINE PMID: 22104576 ] Idioma: Inglês
Tipo de publicação: Artigo de Revista

Background Bone metastatic patients with osteosarcoma have a very poor prognosis. Targeted radiation therapy has been pursued as a valid alternative. The primary end point of this study was progression-free survival (PFS) at 4 months. Patients and methods Twenty-two osteosarcoma patients were treated with Samarium-153 ethylenediaminetetramethylene phosphonic acid ((153)Sm-EDTMP) at various dosages. Administered activities ranged from 150 (3 mCi/kg) to 1140 MBq/kg (30 mCi/kg). Autologous hematopoietic stem cell infusion was carried out on day 14 after the (153)Sm-EDTMP infusion. Results The median PFS was 61 days (18-436 days) and the median overall survival (OS) was 189 days (31-1175 days). PFS and OS for the entire patient population were 32% [95% confidence interval (CI) 16-50] and 76% (95% CI 52-89) at 4 months, respectively. No statistical differences emerged according to (153)Sm-EDTMP administered or 24-h retained activity. One-month pain palliation was only observed in a minority of subjects and in none at 4 months. Conclusions Based on our series, the PFS is dramatically short even when higher activity of (153)Sm-EDTMP is administered. This would mean that, even at high level, (153)Sm-EDTMP is itself ineffective against relapsed osteosarcoma or the residual activity is too low to be active on these particular subsets of patients.
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